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本文用放射免疫方法测定28例慢性肺源性心脏病急性期患者和20例正常人血清EDF 浓度,结果显示:慢性肺源性心脏病组血清 EDF 浓度明显低于正常对照组,P<0.01;随心功能不全程度加重,血清 EDF 浓度明显降低;合并有心房纤颤者血清 EDF 浓度明显低于窦性节律者,P<0.025;血清 EDF 浓度与血红蛋白浓度、右室流出道直径、血清 T_3、T_3浓度呈明显正相关,r 分别为0.5276、0.6242、0.6394、0.6383,P 分别<0.01、<0.01、<0.05、<0.05;慢性肺源性心脏病恢复期患者血清 EDF 浓度较急性期明显升高,P<0.05,但仍低于正常对照组水平,P<0.01。
In this paper, radioimmunoassay was used to determine the serum EDF concentrations in 28 patients with chronic cor pulmonale and 20 normal controls. The results showed that the serum EDF levels in patients with chronic cor pulmonale were significantly lower than those in normal controls (P <0.01). Serum EDF concentration was significantly lower in patients with atrial fibrillation than those in sinus rhythm, P <0.025; EDF concentration of serum, hemoglobin concentration, diameter of right ventricular outflow tract, serum T_3, T_3 (R = 0.5276,0.6242,0.6394,0.6383, P <0.01, <0.01, <0.05, <0.05 respectively). Serum EDF concentrations in patients with chronic cor pulmonale during convalescence were significantly higher than those in acute phase, P <0.05, but still lower than the normal control group, P <0.01.