以往的研究证明,碳氟化合物,如其它许多卤化烃和烃类一样,能致敏哺乳动物心脏,使之在肾上腺素激发试验时产生严重的心律不齐。致敏作用与这些化合物的临界吸入水平和血中浓度有关。本次研究的目的是探索心脏的损害能否显著降低心脏的致敏阈值。选择41只雄性健康小猎犬通过导管插入术使产生心肌梗塞,梗塞的发生由心电图、SGOT改变和本实验结束后作的病理解剖所证实。心肌梗塞后生存下来的30只小猎犬先对照注射0.008 mg/kg剂量的1:1,000肾上腺素5分钟后,再接触被试物质蒸气10分钟,在吸入试验物质蒸气5分钟时,进行静脉注射同样剂量的肾上腺素作激发试验。整个试验期间都作了 Previous studies have shown that fluorocarbons, like many other halogenated hydrocarbons and hydrocarbons, sensitize mammalian hearts to severe arrhythmias during the epinephrine challenge test. Sensitization is related to the critical inhaled levels and blood concentrations of these compounds. The purpose of this study was to explore whether cardiac damage can significantly reduce the sensitization threshold of the heart. Forty-one male health beagle dogs were selected to have a myocardial infarction by catheterization. The incidence of infarction was confirmed by electrocardiogram, SGOT changes, and pathological anatomy at the end of the experiment. Thirty beagle dogs survived myocardial infarction were injected with 1: 1,000 epinephrine at a dose of 0.008 mg / kg for 5 minutes prior to exposure to the test substance vapor for 10 minutes. The same procedure was followed when the test substance vapor was inhaled for 5 minutes The dose of epinephrine for the challenge test. Made throughout the experiment