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目的研究广王不留行醇提物对大鼠慢性膀胱颈梗阻模型逼尿肌中的平滑肌细胞凋亡的影响。方法实验大鼠随机分为空白对照组、造模组、实验组,各15只。参照文献方法制作大鼠膀胱颈梗阻模型。应用TUNEL法检测大鼠逼尿肌平滑肌细胞凋亡情况。结果空白对照组平滑肌凋亡细胞率为15.5%,造模组凋亡细胞率为50.2%,实验组凋亡细胞率为30.4%,各组间比较,差异均有统计学意义(P<0.05)。结论广王不留行醇提物可能通过抑制膀胱逼尿肌平滑肌细胞凋亡,从而改善逼尿肌功能。
Objective To investigate the effects of alcohol extract of Rhodiola rosea on the apoptosis of smooth muscle cells in detrusor muscle of rats with chronic bladder neck obstruction. Methods Experimental rats were randomly divided into blank control group, model group, experimental group, 15 rats each. Reference to the literature method of rat bladder neck obstruction model. TUNEL method was used to detect the apoptosis of rat detrusor smooth muscle cells. Results The percentage of apoptotic cells in control group was 15.5%, that of apoptotic cells in model group was 50.2%, and that in experimental group was 30.4%. There were significant differences among the groups (P <0.05) . Conclusions The ethanol extract of Rhizoma et Radix notoginseng may improve detrusor function by inhibiting the apoptosis of smooth muscle cells of bladder detrusor muscle.