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实验用 Wistar 大鼠72只,随机分为三组,即对照组、10ppm 氟水组和30ppm 氟水组各组动物于实验后5个月及8个月分两批处理进行检查。结果表明,10ppm 氟水组大鼠于实验后8个月、30ppm 氟水组大鼠于实验后5个月及8个月其血清和红细胞中脂质过氧化物含量升高、谷胱甘肽过氧化物酶活性降低,还原型谷胱甘肽含量减少,但超氧化物歧化酶活性无明显改变。提示自由基水平的增高可能是氟病发生机制中的一个重要的中间介导环节。
Seventy-two Wistar rats were randomly divided into three groups: control group, 10ppm fluoride water group and 30ppm fluoride water group. The animals in each group were examined in two batches at 5 and 8 months after the experiment. The results showed that at 10 months after the experiment, rats in 30ppm fluoride group had higher levels of lipid peroxidation in serum and erythrocytes at 5 and 8 months after the experiment, while glutathione Peroxidase activity decreased, reduced glutathione content decreased, but no significant changes in superoxide dismutase activity. It is suggested that the increase of free radicals may be an important intermediate mediator in the pathogenesis of fluorohydrolysis.