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作者对四价恒河猴-人重配轮状病毒(RRV-TV)疫苗的效力能否持续2个流行季节以上,及其预防严重轮状病毒性胃肠炎的能力进行了评估。在接种3剂疫苗的儿童中,第1个流行季节(至1994年6月30日)有1073名儿童(其中疫苗组536人,安慰剂组537人)参与。另1200名儿童(疫苗组592人,安慰剂组608人)仅从第2个流行季节(1994年7月1日~1995年6月30日)开始参与。结果在1995年6月底之前安慰剂组有13例轮状病毒性胃肠炎住院病例;而疫苗组无病例出现。
The authors assessed whether the efficacy of the tetravalent rhesus monkey-human reassortant rotavirus (RRV-TV) vaccine lasts longer than two prevalent seasons and its ability to prevent severe rotavirus gastroenteritis. Among children vaccinated against three doses, 1,073 children (536 in the vaccine group and 537 in the placebo group) were involved in the first epidemic season (as of June 30, 1994). Another 1,200 children (592 in the vaccine group and 608 in the placebo group) participated only from the second prevalent season (July 1, 1994 to June 30, 1995). Results In the placebo group, there were 13 hospitalizations for rotavirus gastroenteritis in the placebo group by the end of June 1995; none of the vaccine groups were present.