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用人乙型肝炎病毒(HHBV·)感染树鼩(Tree shrews)后,取其HBsAg及(或)HBeAg阳性的树齣血清传代感染另一批树鼩;18只树鼩分四批感染至第四代,经检测发现17只树鼩血清或肝细胞中HBV标志物阳性(94.4%);血清转氨酶(SGPT)升高,肝组织有不同程度的炎症变化。此结果表明HHBV能够在树鼩间连续传代复制,为人乙型肝炎病毒感染树鼩动物模型的建立提供又一佐证。
After tree shrews were infected with human hepatitis B virus (HHBV ·), another tree shrew was subcultured with herds of HBsAg and / or HBeAg-positive trees; 18 trees were infected in four batches to the fourth The results showed that the HBV markers in serum or hepatocyte of 17 trees were positive (94.4%). Serum aminotransferase (SGPT) increased and liver tissue had different degree of inflammatory changes. This result indicates that HHBV can be continuously passaged and replicated between tree shrews, which provides further evidence for establishing the animal model of tree shrew infection with human hepatitis B virus.