目的探讨小泛素样修饰蛋白4(SUMO4)基因163 A/G多态性与2型糖尿病肾病(DN)的相关性。方法运用聚合酶链反应限制性片段长度多态性(PCR-RFLP)方法对232例T2DM患者,其中正常白蛋白尿103例(N-UAlb组)、微量白蛋白尿65例(M-UAlb组)、大量白蛋白尿64例(I-UAlb组),以及102名健康对照(NC组)的SUMO4基因163 A/G多态性进行检测,并比较各组间基因型频率、等位基因频率及相关临床资料。结果 NC组和T2DM组基因型和等位基因频率无统计学差异;M-UAlb和L-UAlb组的GA基因型频率高于N UAlb组(P<0.05)。结论在昆明地区汉族人群中,SUMO4基因GA基因型可能是DN发生的危险因素。 Objective To investigate the association of the 163 A / G polymorphism of the SUMO4 gene with type 2 diabetic nephropathy (DN). Methods 232 cases of T2DM were diagnosed by PCR-RFLP, including 103 cases of normal albuminuria (N-UAlb group) and 65 cases of microalbuminuria (M-UAlb group) ), 64 patients with massive albuminuria (I-UAlb group) and 102 healthy controls (NC group). The polymorphisms of SUMO4 gene 163 A / G were detected. The genotype frequency, allele frequency And related clinical data. Results There was no significant difference in genotype and allele frequency between NC group and T2DM group. GA genotypes in M-UAlb and L-UAlb groups were higher than that in N UAlb group (P <0.05). Conclusions GA genotype of SUMO4 gene may be a risk factor for DN in Han nationality in Kunming.