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目的:探讨皮层肌动蛋白(CORTACTIN)在胃癌组织中的表达及其对预后的影响。方法:采用免疫组化SP法检测56例胃癌及对应癌旁组织中CORTACTIN的表达,分析其与胃癌临床特征和预后的关系。结果:CORTACTIN在胃癌组织中的阳性表达率显著高于对应的癌旁组织(69.6%vs.21.4%,P=0.000),CORTACTIN在胃癌中的阳性表达与肿瘤病理分化程度、淋巴结转移、TNM分期和浸润深度有关(P=0.009,P=0.014,P=0.019,P=0.021);CORTACTIN阳性表达是胃癌患者预后不良的独立影响因素。结论:CORTACTIN在胃癌组织中表达升高,并且与患者预后相关,提示CORTACTIN可能在胃癌中发挥促进侵袭转移的作用。
Objective: To investigate the expression of cortical actin (CORTACTIN) in gastric carcinoma and its effect on prognosis. Methods: The expression of CORTACTIN in 56 cases of gastric cancer and corresponding paracancerous tissues was detected by immunohistochemical SP method. The relationship between CORTACTIN and clinical features and prognosis of gastric cancer was analyzed. Results: The positive expression rate of CORTACTIN in gastric cancer tissues was significantly higher than that in corresponding adjacent tissues (69.6% vs.21.4%, P = 0.000). The positive expression of CORTACTIN in gastric cancer was correlated with the degree of tumor differentiation, lymph node metastasis, TNM stage And invasive depth (P = 0.009, P = 0.014, P = 0.019, P = 0.021). CORTACTIN positive expression was an independent prognostic factor for gastric cancer patients. CONCLUSIONS: The increased expression of CORTACTIN in gastric cancer tissues correlates with the prognosis of patients, suggesting that CORTACTIN may play an important role in gastric cancer invasion and metastasis.