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目的 探讨急性白血病 (AL)早期死亡危险因素。方法 采用病例对照方法将早期死亡及非早期死亡AL患者分为A、B两个组。对可能引起早期死亡的 15项指标进行单因素分析 ,再对单因素分析中具有统计学意义的指标进行Logistic回归分析 ,寻找早期死亡的危险因素。结果 多器官功能衰竭、骨髓中幼稚细胞比例≥80 %、颅内出血、血小板计数≤ 2 0× 10 9/L、高热 (T≥ 39 0℃ )、发病年龄≥ 6 0岁 6项指标进入回归方程。结论 早期死亡的危险因素按相对危险度由大到小排列为 ,多器官功能衰竭、骨髓幼稚细胞比例≥ 80 %、颅内出血、血小板计数≤ 2 0× 10 9/L、高热、发病年龄≥ 6 0岁。
Objective To investigate the risk factors for early death of acute leukemia (AL). Methods A case-control method was used to divide the patients with early death and non-early-death AL into A and B groups. Univariate analysis of 15 items that could cause early death and logistic regression analysis of statistically significant indicators in univariate analysis were performed to find the risk factors for early death. Results Multiple organ failure, the proportion of immature cells in bone marrow≥80%, intracranial hemorrhage, platelet count≤20 × 109 / L, high fever (T≥39 0 ℃), and age at onset≥60 years old, all reached the regression equation . Conclusion The risk factors of early death are ranked according to the relative risk as follows: multiple organ failure, ratio of bone marrow blast cells ≥ 80%, intracranial hemorrhage, platelet count ≤ 2 0 × 10 9 / L, fever, onset age ≥ 6 0 years old.