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蛋白激酶Cε(PKCε)是PKC家族中的一员,属于nPKC亚家族。抑制PKCε后可以降低肝胰岛素清除率,增强功能缺陷的胰岛β细胞对葡萄糖刺激的反应,增加胰岛素分泌,从而使胰岛β细胞分泌功能得到根本的改善。本文就蛋白激酶Cε与胰岛β细胞分泌功能做一综述。
Protein kinase Cε (PKCε) is a member of the PKC family and belongs to the nPKC subfamily. Inhibition of PKCε can reduce hepatic insulin clearance and enhance the response of glucose-stimulated insulin-deficient islet β cells to insulin secretion, so that the secretion of pancreatic β-cells is fundamentally improved. This article reviews the role of protein kinase Cε and pancreatic β-cell secretion.