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在证实了人Ｍφ系Ｕ９３７细胞ＣｌｑＲ在生理离子强度（Ｉ０．１５）下可与１２５Ｉ－Ｃｌｑ结合的基础上研究了ＣｌｑＲ对Ｕ９３７细胞吞噬酵母多糖颗粒（Ｚ）的调节作用。该细胞不吞噬Ｚ，但可吞噬Ｃｌｑ或ＩｑＧ调理的Ｚ（ＣＺ、ＩＺ），若以Ｃｌｑ和ＩｇＧ调理（ＩＣＺ），吞噬指数分别是ＣＺ和ＩＺ的６倍和２．５倍。将调理颗粒热灭活，或加入兔抗人ＣｌｑＦ（ａｂ’）２，或以高浓度Ｃｌｑ或抗人ＣｌｑＲｍＡｂＥ８预处理Ｕ９３７细胞，均可不同程度地抑制对ＣＺ或ＩＣＺ的吞噬，但Ｃｌｑ预处理却使对ＩＺ和Ｚ的吞噬增强。资料表明，Ｕ９３７细胞通过ＣｌｑＲ介导对酵母多糖颗粒的吞噬，且与ＦｃγＲ有协同作用。
The regulatory effect of ClqR on the phagocytosis of Z9 in U937 cells was studied on the basis of confirming that ClqR of human Mφ line U937 cells binds to 125I-Clq under physiological ionic strength (I0.15). The cells did not phagocytose Z, but phagocytosed Clq or IqG-conditioned Z (CZ, IZ), with 6 and 2.5 fold CZ and IZ, respectively, with Clq and IgG conditioning (ICZ). Heat-inactivated particles or rabbit anti-human ClqF (ab ’) 2, or pretreated U937 cells with high concentrations of Clq or anti-human ClqRmAbE8 all inhibited phagocytosis of CZ or ICZ to varying degrees, but Clq pretreatment But to IZ and Z phagocytosis. The data indicate that U937 cells mediate the phagocytosis of zymosan particles through ClqR and have a synergistic effect with Fc [gamma] R.