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目的：观察甘露醇对腹腔镜子宫切除患者术后苏醒和呼吸恢复的影响。方法将60例全凭静脉全身麻醉下行择期腹腔镜子宫切除患者（ASA Ⅰ～Ⅱ）随机分为三组：对照组（A 组）、利尿组（B 组）和脱水组（C 组），每组20例。麻醉诱导和维持给予同样的靶控输注（ TCI）药物和程序。CO2气腹30 min，A 组给予氯化钠注射液2.5 ml/ kg，80滴/ min；B 组给予呋塞米注射液，用氯化钠注射液稀释至2.5 ml/ kg；C 组给予20％甘露醇注射液。开始缝合皮肤时停止麻醉药物输注。分别于诱导前（T0）、插管后10 min（T1）、气腹后60 min（T2）、拔管后10 min（T3）抽取动脉血，检测动脉血氧分压（PaO2）、动脉血二氧化碳分压（PaCO2）；记录患者苏醒时间（手术结束计时）、拔管时间（手术结束计时）、昏迷评分、苏醒评分。结果与 A 组比较，B、C 组苏醒时间、拔管时间明显缩短（P ＜0.05），昏迷评分、苏醒评分显著增加（P ＜0.05）；与 B 组比较，C 组苏醒时间、拔管时间缩短（P ＜0.05），昏迷评分增加（P ＜0.05）。与 A 组比较，C 组 T3时的PaO2明显升高（P ＜0.05），PaCO2显著降低（P ＜0.05）。结论甘露醇能有效改善 CO2气腹头低臀高截石位腹腔镜子宫切除患者术后认知和苏醒质量。“,”Objective To investigate the effects of mannitol on the postoperative recovery of patients undergoing laparoscopic hysterectomy in trendelenburg position. Methods Sixty patients(ASA Ⅰ - Ⅱ)scheduled to underwent laparoscopic hysterec-tomy under total intraveous anesthesia were randomly divided into three groups with 20 cases in each group:control group(group A),furosemide group(group B)and mannitol group(group C);anesthesia was induced with fentanyl,propofol,and vecuroni-um to facilitate tracheal intubations. Thirty minutes after pneumoperitoneum,patients were administrated as followed:Group A:Saline 2. 5 ml/ kg,80 drips/ min;Group B:furosemide 0. 5 mg/ kg,add Saline to 2. 5 ml/ kg;Group C:mannitol. Mean arterial pressure(MAP)were monitored and recorded;samples of right radial artery were obtained to measure arterial oxygen pressure (PaO2 ),arterial carbon dioxide partial pressure(PaCO2 )before induction(T0 ),10 min after intubation(T1 ),60 min after pneumoperitoneum(T2 )and 10 min after extubation(T3 );the time of awake and extubation were recorded. Results Compared with group A,the times of awake and extubation in group B and group C were significantly decreased(P < 0. 05),and Glasgow coma scale(GCS)was significantly increased(P < 0. 05). Compared with group B,the times of awake and extubation in group C were significantly decreased( P < 0. 05),and GCS and recovery scale( Steward)were significantly increased( P < 0. 05). Compared with group A at T3 ,the PaO2 of patients in group C was significantly increased(P < 0. 05),while PaCO2 significantly decreased(P < 0. 05). Conclusion Mannitol can improve the recovery of postoperative respiratory and cognitive function of the patients undergoing laparoscopic hysterectomy in trendelenburg position.