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目的探讨HBV感染夫妇的胚胎的发育情况和IVF结局。方法病例对照研究:将仅一方感染HBV的夫妻与未感染的夫妻进行1∶2配对,配对指标为:女方年龄,月经周期,基础FSH,不孕原因,原发还是继发不孕,不孕年限,第几次周期,卵巢刺激方案是长方案还是短方案,IVF还是ICSI。比较这两组人群的胚胎在受精率,卵裂率,着床率,临床妊娠率,流产率和活产率方面有无差异。结果仅一方感染HBV的夫妻与未感染的夫妻在配对指标方面没有显著性差异。除了较低的卵裂率外(97.7%比98.8%;P<0.05),仅一方感染HBV的夫妻的胚胎的受精率,着床率,临床妊娠率,流产率和活产率方面与对照组比较没有差异(P均>0.05)。结论HBV感染夫妇和未感染夫妇比较,除了卵裂率较低外,HBV感染夫妇的胚胎继续发育的潜能和IVF结局与未感染者相似。
Objective To investigate the development of embryos and the outcome of IVF in couples with HBV infection. Methods Case-control study: Only one party infected with HBV and uninfected couples 1: 2 matching, matching indicators: the woman’s age, menstrual cycle, basic FSH, causes of infertility, primary or secondary infertility, infertility Years, the number of cycles, ovarian stimulation program is long or short program, IVF or ICSI. Comparison of these two groups of embryos in fertilization rate, cleavage rate, implantation rate, clinical pregnancy rate, abortion rate and live birth rate are there any differences. Results Only one party infected with HBV and uninfected couples showed no significant difference in matching index. In addition to lower cleavage rate (97.7% vs 98.8%; P <0.05), fertilization rate, implantation rate, clinical pregnancy rate, abortion rate and live birth rate were significantly higher in the couples with HBV infection than those in the control group There was no difference (P> 0.05). Conclusions Compared with uninfected couples, HBV-infected couples showed similar potential and IVF outcome to uninfected couples except for the lower cleavage rate.