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目的:回顾性总结58例子宫内膜癌的临床病理特点及雌激素受体(ER)、孕激素受体(PR)的表达情况,从而指导进一步治疗。方法:回顾性分析58例子宫内膜癌患者的临床表现、病理特征、ER、PR的表达情况。结果:子宫内膜癌以阴道出血为最突出表现,糖尿病、高血压、肥胖是子宫内膜癌的高危因素,经阴道多普勒超声检查是重要的检查手段,诊刮是术前确诊的主要方法。广泛子宫切除术可作为子宫内膜癌的基本术式。ER、PR的表达随病理分级级别的升高而逐渐降低。结论:糖尿病是绝经后子宫内膜癌的高危因素,子宫内膜癌的盆腔淋巴结转移率随病理分期增高而升高。应以包括ER、PR检测在内的病理检查为依据指导放疗、化疗或激素治疗等辅助治疗。
OBJECTIVE: To retrospectively summarize the clinicopathological features and the expression of estrogen receptor (ER) and progesterone receptor (PR) in 58 cases of endometrial carcinoma so as to guide further treatment. Methods: A retrospective analysis of 58 cases of endometrial cancer patients with clinical manifestations, pathological features, ER, PR expression. Results: Vaginal bleeding was the most prominent manifestation of endometrial cancer. Diabetes mellitus, hypertension and obesity were the risk factors of endometrial cancer. Transvaginal Doppler ultrasonography was an important method of examination, and curettage was the main preoperative diagnosis method. Womb hysterectomy can be used as the basic operation of endometrial cancer. The expression of ER and PR gradually decreased with the increase of pathological grade. Conclusion: Diabetes mellitus is a risk factor for endometrial cancer in postmenopausal women. The rate of pelvic lymph node metastasis in endometrial cancer increases with the increase of the pathological stage. Radiotherapy, chemotherapy or hormone therapy and other adjuvant therapy should be guided by pathology including ER and PR tests.