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目的 :探讨糖尿病性白内障囊外摘除(ECCE)后房型人工晶体(IOL)植入术前后 ,血清中白细胞介素6(interleukin -6,IL -6) ,肿瘤坏死因子(tumornecrosisfactor-α,TNF-α)动态监测的临床意义。方法 :用放射免疫法(RIA)对39例糖尿病白内障患者 ,39例非糖尿病白内障患者 ,ECCE、IOL植入术前 ,术后1、3、7、14、30、90天血清IL -6、TNF -α进行测定 ,并与正常对照组进行对照。结果 :术前糖尿病组血清IL -6、TNF -α比非糖尿病组、正常对照组显著升高(P均<0.05) ;术后除糖尿病组中增殖性糖尿病性视网膜病变组(prolifarativediabeticretinopathy,PDR)外 ,其余糖尿病与非糖尿病组血清IL-6、TNF -α含量变化规律一致。结论 :PDR患者在ECCE及IOL植入术前后血清IL -6、TNF -α含量变化异常与术后并发症及疗效有关
OBJECTIVE: To investigate the changes of serum interleukin-6 (IL-6), tumor necrosis factor-α (TNF) in patients with diabetic cataract extracapsular cataract extraction (ECCE) posterior chamber intraocular lens implantation -α) dynamic monitoring of clinical significance. Methods: Radioimmunoassay (RIA) was performed on 39 cases of diabetic cataract patients, 39 cases of non-diabetic cataract patients, ECCE, IOL before, 1, 3, 7, 14, 30, TNF-α were measured and compared with the normal control group. Results: The levels of IL-6 and TNF-α in pre-diabetic group were significantly higher than those in non-diabetic group and normal control group (all P <0.05). In addition to the proliferative diabetic retinopathy group (PDR) , The rest of the diabetic and non-diabetic serum IL-6, TNF-α content changes consistent. Conclusion: The abnormal changes of IL-6 and TNF-α levels in patients with PDR before and after ECCE and IOL implantation are related to postoperative complications and curative effects