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目的探讨PTEN基因在喉鳞状细胞癌中的表达及其临床意义。方法应用RT-PCR方法检测30例喉鳞癌组织及20例癌旁组织PTEN mRNA的表达。结果(1)癌组织PTEN表达率明显低于癌旁组织,差异有统计学意义(P<0.05);(2)TNM分期Ⅰ～Ⅱ期与Ⅲ～Ⅳ期相比较,PTEN表达差异有统计学意义(P<0.05);(3)高中分化鳞癌与低分化鳞癌PTEN表达阳性率差异有统计学意义(P<0.05);(4)有淋巴结转移组和无淋巴结转移组比较,PTEN检出阳性率差异有统计学意义(P<0.05)。结论PTEN的表达与喉鳞癌的临床病理特征、生物学行为存在密切关系,PTEN基因可能在喉鳞癌的发生、发展中起重要作用,其表达可能成为喉鳞癌重要分子生物学指标。
Objective To investigate the expression of PTEN gene in laryngeal squamous cell carcinoma and its clinical significance. Methods RT-PCR was used to detect the expression of PTEN mRNA in 30 cases of laryngeal squamous cell carcinoma and 20 cases of paracancerous tissues. Results (1) The expression of PTEN in cancer tissues was significantly lower than that in paracancerous tissues (P <0.05). (2) The expression of PTEN in stage Ⅰ ~ Ⅱ of TNM stage was statistically different from that in stage Ⅲ ~ Ⅳ (P <0.05). (3) The positive rate of PTEN expression in well-differentiated squamous cell carcinoma and poorly differentiated squamous cell carcinoma was significantly different (P <0.05). (4) Compared with lymph node metastasis group and non-lymph node metastasis group, PTEN The positive rate of difference was statistically significant (P <0.05). Conclusions The expression of PTEN is closely related to the clinicopathological features and biological behavior of laryngeal squamous cell carcinoma. PTEN gene may play an important role in the occurrence and development of laryngeal squamous cell carcinoma, and its expression may be an important molecular biological index for laryngeal squamous cell carcinoma.