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目的观察并分析复方丹参注射液联合局部亚低温对脑梗死患者神经功能缺损以及自由基的影响。方法将2013年7月-2014年8月接受治疗的120例脑梗死患者作为研究的对象,按照随机分配的方法将患者分为试验组和对照组各60例,对照组患者给予血栓通注射液联合局部亚低温治疗,试验组患者给予复方丹参注射液联合局部亚低温治疗,观察并对比2组患者的临床治疗效果。结果试验组总有效率为90.00%明显优于对照组的66.67%(P<0.05)。试验组治疗后神经功能改善程度明显优于治疗前(P<0.05),且治疗后神经缺损评分明显优于对照组(P<0.05)。试验组治疗后SOD、LPO改善程度明显优于治疗前和对照组,差异均有统计学意义(P<0.05)。结论复方丹参注射液联合局部亚低温治疗脑梗死可取的较为满意的临床效果,可有效的降低患者神经功能的缺损,提高SOD活性,降低LPO含量。
Objective To observe and analyze the effect of Fufang Danshen injection combined with local mild hypothermia on neurological deficits and free radicals in patients with cerebral infarction. Methods A total of 120 patients with cerebral infarction treated from July 2013 to August 2014 were enrolled in this study. Patients were divided into experimental group and control group according to the method of random assignment. 60 patients in the control group were treated with Xueshuantong injection Combined with local mild hypothermia, the patients in the test group were given Fufang Danshen injection combined with local mild hypothermia. The clinical effects of the two groups were observed and compared. Results The total effective rate of the experimental group was 90.00%, which was significantly better than that of the control group (66.67%, P <0.05). The improvement of neurological function in the experimental group was better than that before treatment (P <0.05), and the score of neurological deficit after treatment was obviously better than that of the control group (P <0.05). After treatment, the improvement of SOD and LPO in the experimental group was significantly better than that before treatment and in the control group (P <0.05). Conclusion The compound Danshen injection combined with local mild hypothermia may be more satisfactory for clinical treatment of cerebral infarction, which can effectively reduce the neurological deficit, improve the activity of SOD and reduce the content of LPO.