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目的探讨治疗性血浆置换术(Therapeutic Plasma exchange,TPE)在急性重症有机磷中毒中的作用。方法对常规治疗中毒症状缓解不明显的11例急性重症有机磷中毒患者进行TPE治疗,观察患者TPE前后患者部分生化指标变化,患者神志开始恢复时间及完全恢复时间。结果患者TPE治疗后ChE、CK、CK-MB、LDH指标均较TPE治疗前有显著改善(P<0.01),ALT、AST、BUN、ALB有明显改善(P<0.05)。结论用TPE治疗急性重症有机磷中毒疗效显著,能及时、有效去除毒素,补充有活力的胆碱脂酶及血浆有效成分,改善病人症状。
Objective To investigate the role of therapeutic Therapeutic Plasma Exchange (TPE) in acute severe organophosphorus poisoning. Methods Eleven patients with acute severe organophosphorus poisoning who did not alleviate the symptoms of conventional treatment were treated with TPE. The biochemical indexes of patients before and after TPE were observed, and the recovery time and complete recovery time of patients’ conscious mind began. Results After treatment with TPE, the indexes of ChE, CK, CK-MB and LDH were significantly improved (P <0.01) and the ALT, AST, BUN and ALB were significantly improved (P <0.05). Conclusion TPE treatment of acute severe organophosphorus poisoning significant effect, timely and effective removal of toxins, added with active choline lipase and plasma active ingredients to improve the patient’s symptoms.