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目的:为剖宫产术合理预防使用抗菌药物提供参考。方法:回顾性调查我院2013年1-12月(干预前)手术开始前0.5~2 h给予预防用药的剖宫产术患者472例及2014年1-12月(干预后)钳夹脐带后给予抗菌药物的剖宫产术患者431例,对其抗菌药物使用情况进行统计分析。结果:干预后,预防用药给药时机合理率为100%,选择药物品种合理率从64.41%上升至93.50%,预防用药疗程合理率从50.21%上升至92.11%,用法用量合理率也有了明显改善,与干预前比较差异均有统计学意义(P<0.05)。干预后,人均抗菌药物费用从(103.25±13.62)元下降至(54.61±27.21)元,人均住院费用从(5 574.8±117.6)元下降至(5 427.4±106.7)元,与干预前比较差异均有统计学意义(P<0.05)。结论:临床药师通过药学干预,能明显提高剖宫产术预防使用抗菌药物的合理率,使我院抗菌药物使用更加规范、合理。
Objective: To provide a reference for rational prevention of antibacterial drugs in cesarean section. Methods: A retrospective survey of 472 cesarean sections in our hospital from January to December 2013 (pre-intervention) for prophylaxis 0.5 to 2 hours before surgery and January-December 2014 (after intervention) after clamping the umbilical cord 431 cases of cesarean section were given antimicrobial agents, and their antibacterials were statistically analyzed. Results: After the intervention, the rationality of the timing of prophylaxis administration was 100%, the rational rate of drug selection varied from 64.41% to 93.50%, the reasonable rate of prophylaxis treatment increased from 50.21% to 92.11%, and the reasonable dosage of usage was significantly improved , Which were significantly different from those before intervention (P <0.05). After intervention, the average per capita cost of antimicrobial drugs decreased from (103.25 ± 13.62) yuan to (54.61 ± 27.21) yuan, and the per capita hospitalization cost decreased from (5774.8 ± 117.6) yuan to (5247.4 ± 106.7) yuan, There was statistical significance (P <0.05). Conclusion: The clinical pharmacist can significantly improve the reasonable rate of preventing the use of antibiotics by cesarean section through pharmacy intervention, and make the use of antibacterials in our hospital more standardized and reasonable.