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目的观察黄连素联合二甲双胍治疗2型糖尿病的疗效和不良反应。方法32例2型糖尿病患者被随机分成2组,联合组给予口服黄连素600 mg 3次/d饭后服用;二甲双胍0.25 g 3次/d吃第一口饭时服用。单药组:二甲双胍0.25~0.5 g3次/d吃第一口饭时服用。连用3个月后评定疗效。结果32例可评价疗效和毒副作用患者中,联合组:显效2例,有效12例,总有效率87.5%(14/16);单药组:显效1例,有效11例,总有效率75.0%(12/16),联合组无严重不良反应。结论黄连素联合二甲双胍治疗2型糖尿病的疗效肯定,不良反应轻微,患者耐受性良好。
Objective To observe the efficacy and adverse reactions of berberine and metformin in the treatment of type 2 diabetes mellitus. Methods 32 patients with type 2 diabetes mellitus were randomly divided into 2 groups. The combination group was given oral berberine 600 mg 3 times / d after meals; metformin 0.25 g 3 times / d when taking the first bream meal. Single drug group: metformin 0.25 ~ 0.5 g3 times / d when taking the first meal to take. Used 3 months after the assessment of efficacy. Results Among the 32 evaluable curative and toxic side effects, the combination group was markedly effective in 2 cases and effective in 12 cases, with a total effective rate of 87.5% (14/16). In the single drug group, 1 was markedly effective and 11 effective, with a total effective rate of 75.0 % (12/16), the combination group no serious adverse reactions. Conclusion The efficacy of berberine and metformin in the treatment of type 2 diabetes is affirmative with mild adverse reactions and good patient tolerance.