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目的研究老龄供肾在青年受者体内的病理学改变,探讨老龄供肾移植的安全性。方法研究对象选择2008年1月至2008年12月期间在广州医科大学附属第二医院移植科实施亲属活体供肾移植的14例老龄供者(年龄>55岁)和14例青年受者(年龄<30岁)。对每例老龄供肾进行零时活组织检查(活检),对接受老龄供肾的青年受者在移植后6个月进行常规的移植肾活检。观察老龄供肾移植后的肾脏组织病理结构改变。结果老龄供肾移植至青年受者体内6个月后组织病理结构发生改变:肾小动脉病变程度较移植前减轻;肾小动脉硬化指数较移植前减轻(P<0.05);肾小球硬化比例移植前后变化不大(P>0.05)。纤维连接蛋白(FN)水平较移植术前表达水平降低,但差异无统计学意义(P>0.05);层黏连蛋白(LN)表达水平较移植前降低(P<0.05)。结论老龄供肾移植到青年受者体内后,其组织病理学结构有所改善。
Objective To study the pathological changes of aged donor kidney in young recipients and explore the safety of old donor kidney transplantation. Methods Subjects From January 2008 to December 2008, 14 cases of elderly donors (aged> 55 years) and 14 cases of young recipients (age <30 years old). A zero-hour biopsy (biopsy) was performed on each of the elderly donor kidneys and a routine transplant renal biopsy was performed on young recipients of the aged donor kidneys 6 months after transplantation. Observe the pathological changes of kidney tissue after old donor kidney transplantation. Results The pathological changes of the grafts were observed in the grafts of aged donor kidneys after 6 months. The pathological changes of renal arterioles were lesser than those before transplantation. The index of sclerosis of renal arterioles was relieved before transplantation (P <0.05) Before and after transplantation changed little (P> 0.05). The level of fibronectin (FN) was lower than that before transplantation, but the difference was not statistically significant (P> 0.05). The level of laminin (LN) was lower than that before transplantation (P <0.05). CONCLUSIONS: The histopathology of aged donor kidneys after transplantation into young recipients has been improved.