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目的 :评价阻塞性睡眠呼吸暂停 (OSA)合并高血压(HT)与血管紧张素转换酶 (ACE)基因多态性的关系。方法 :采用病例对照研究方法 ,以 OSA的严重程度将研究对象分为正常对照组 (6 8人 )、HT组 (45人 )、轻度 OSA合并 HT组 (2 7人 )、中重度 OSA合并 HT组 (31人 ) ,共 171例 ;(2 )观察 ACE I/ D多态在一个 OSA典型家系中的分布。结果 :(1) ACE I/ D等位基因的频率分布如下 :中重度 OSA合并 HT组 ,I等位基因的频率显著高于其他各组 (P<0 .0 0 1) ;而正常对照组、HT组和轻度 OSA合并 HT组之间 I等位基因频率分布没有显著性差别 ;(2 )在一个典型 OSA家系中 I等位基因呈高频率出现。结论 :ACE基因 I等位基因与中重度 OSA显著相关 ,遗传因素是影响中重度 OSA合并 HT发病的重要因素
Objective: To evaluate the relationship between obstructive sleep apnea (OSA) and hypertension (HT) and angiotensin-converting enzyme (ACE) gene polymorphisms. Methods: A case-control study was conducted to divide the subjects into normal control group (68 patients), HT group (45 patients), mild OSA combined HT group (27 patients) and moderate-to-severe OSA HT group (31), a total of 171 cases; (2) to observe ACE I / D polymorphism in a typical OSA family distribution. Results: (1) The frequency distribution of ACE I / D allele was as follows: The frequency of I allele was significantly higher in moderate-severe OSA with HT group than in other groups (P <0.01); while in normal control group There was no significant difference in the frequency distribution of I allele between HT group and mild OSA with HT group. (2) The I allele appeared in high frequency in a typical OSA family. Conclusion: The ACE gene I allele is significantly associated with moderate and severe OSA. Genetic factors are important factors that influence the pathogenesis of moderate and severe OSA complicated with HT