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创伤后应激障碍(posttraumatic stress disorder,PTSD)是指个体由于经历对生命具有威胁的事件或严重的创伤,导致一系列精神症状长期持续的精神障碍。PTSD可通过交感神经兴奋、下丘脑-垂体-肾上腺轴和肾素-血管紧张素系统引起各种应激激素如茶酚胺、皮质激素、胰高血糖素、肾素等的释放。而心血管系统是多种应激因素作用的首要靶器官,它在应激机体适应调控中具有非常重要的作用。多项研究表明PTSD患者常有心率加快、血压升高、心律失常等心血管系统症状出现。PTSD反应了应激反应系统的异常调节,而这种调节的异常与心血管疾病的发病机理有着一定的关联。
Posttraumatic stress disorder (PTSD) refers to a group of mental disorders that cause long-term mental symptoms as a result of life-threatening events or severe trauma. PTSD causes the release of various stress hormones such as catecholamines, corticosteroids, glucagon, renin and the like through sympathetic nerve excitation, the hypothalamic-pituitary-adrenal axis, and the renin-angiotensin system. The cardiovascular system is the primary target organ of a variety of stress factors, which plays a very important role in the adaptive regulation of stress. A number of studies have shown that PTSD patients often have accelerated heart rate, blood pressure, arrhythmia and other cardiovascular system symptoms. PTSD reflects the abnormal regulation of the stress response system, and this regulation of abnormalities and the pathogenesis of cardiovascular disease have a certain relevance.