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目的 比较去甲长春花碱 (NVB)联合铂类方案和CAP(环磷酰胺 ,阿霉素和顺铂 )方案对晚期非小细胞肺癌 (non -small -celllunfcancer ,NSCLC)的疗效与毒性。方法 统计分析用NVB联合铂类方案及CAP方案治疗的 49例晚期NSCLC临床资料。结果 NVB联合铂类方案组有效率为 48 15 % ( 13/2 7) ,其中CR 1例 ;CAP方案组有效率为 36 36% ( 8/2 2 ) ,毒性反应主要为骨髓受抑和恶心呕吐。结论 NVB联合铂类方案是治疗晚期NSCLC的一种有效、安全的化疗方案
Objective To compare the efficacy and toxicity of norvincine (NVB) combined with platinum and CAP (cyclophosphamide, doxorubicin and cisplatin) in the treatment of advanced non-small cell lung cancer (NSCLC). Methods The clinical data of 49 patients with advanced NSCLC treated with NVB combined with platinum regimen and CAP regimen were statistically analyzed. Results The effective rate of NVB combined with platinum group was 48 15% (13/2 7), of which 1 case was CR. The effective rate of CAP group was 36 36% (8/2 2). The main toxicities were bone marrow suppression and nausea Vomit. Conclusion NVB combined with platinum regimen is an effective and safe chemotherapy regimen for advanced NSCLC