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黑色素瘤是最主要皮肤致死性恶性肿瘤,黑色素瘤患者死亡的主要原因是远处转移,常为脑转移。微环境在肿瘤的发生和转移中起着关键的作用,为了治疗或预防转移,必须阐明播散的肿瘤细胞与转移性器官微环境之间的相互作用。然而,大脑间质细胞在促进转移性生长中的作用却知之甚少。星形胶质细胞的主要功能是大脑损伤后修复和形成胶质瘢痕,部分因为通过介导神经炎症,但是星形胶质细胞在
Melanoma is the most important skin-deadly malignant tumor. The main cause of death of melanoma is distant metastasis, often brain metastasis. The microenvironment plays a key role in tumorigenesis and metastasis. In order to treat or prevent metastasis, the interaction between the disseminated tumor cells and the metastatic organ microenvironment must be elucidated. However, the role of brain stromal cells in promoting metastatic growth is poorly understood. The main function of astrocytes is the repair and formation of glial scar after brain injury, partly because of the mediation of neuroinflammation, but astrocytes in