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目的 :为了解血清透明质酸 ( HA)含量变化与常见恶性血液病及其病期之间的关系 ,探讨其临床意义。方法 :对 5 4例恶性血液病的 CR期、NR期、复发期、终末期用放免法测定血清 HA含量。结果 :恶性血液病组血清 HA含量均高于正常对照组 ( P<0 .0 1)。而 NR、复发和终末期患者 ,尤其是合并有肝功能损害、肺部感染和严重贫血者 HA增高更显著 ( P<0 .0 1)。结论 :恶性血液病血清 HA呈中、重度增高提示复发、难治或肝肺等等重要脏器浸润、功能受损、预后不良
Objective : To explore the relationship between the change of serum hyaluronic acid (HA) content and common hematological malignancies and their disease stages, and to explore its clinical significance. Methods : Serum HA was determined by radioimmunoassay in 54 patients with malignant hematological disease at CR stage, NR stage, relapse stage, and end-stage stage. Results: The serum HA content in the hematological malignancy group was higher than that in the normal control group (P < 0.01). Patients with NR, recurrence, and end-stage disease, especially with liver function impairment, pulmonary infection, and severe anemia, had a significantly higher HA (P < 0.01). Conclusion : The high and middle severity of HA in hematological malignancies indicates that important organs such as recurrence, refractory or hepatopulmonary infiltration, impaired function, poor prognosis, etc.