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利用电化学聚合的方法制备了聚四氨基酞菁酮[Cu(TAPc)]微型传感器,并探讨了微型传感器对一氧化氮(NO)的电化学响应.结果表明,电化学聚合Cu(TAPc)微型传感器对NO具有良好的催化氧化作用.示差脉冲伏安法(DPV)和示差脉冲安培法(DPA)的结果表明,该传感器对NO的响应具有较低的检测限和较高的灵敏度.NO的浓度在1.20×10~(-8)～1.00×10~(-6)mol/L范围内与传感器的电流响应呈线性关系,相关系数为0.9998;检出限为6.00×10~(-9)mol/L.生物体内常见共存物质如抗坏血酸、儿茶酚胺类神经递质及其代谢产物、NO的降解产物NO_2~-等不干扰NO的测定.所研制的微型传感器可以满足NO的活体分析的要求.
(Cu (TAPc)] micro-sensor was prepared by electrochemical polymerization, and the electrochemical response of the micro-sensor to nitric oxide (NO) was discussed.The results showed that electrochemical polymerization of Cu (TAPc) Micro-sensor has good catalytic oxidation effect on NO.Results of differential pulse voltammetry (DPV) and differential pulse amperometry (DPA) show that the sensor has a lower detection limit and higher sensitivity to NO.NO The linearity was linear with the current response in the range of 1.20 × 10 -8 -8.00 × 10 -6 mol / L with a correlation coefficient of 0.9998. The detection limit was 6.00 × 10 -9 ) mol / L. Common coexisting substances in vivo such as ascorbic acid, catecholamine neurotransmitters and their metabolites, NO degradation products such as NO 2 ~ - do not interfere with the determination of NO.The developed micro-sensor can meet the requirements of NO in vivo analysis .