提出了一种基于Hertz模型的最优化方法,并研究了不同质量浓度(0,50,100,150和200μg/mL)的白藜芦醇培养36 h后的乳腺癌细胞(MCF-7)的杨氏模量和能量耗散变化情况。实验结果表明:基于Hertz模型的最优化方法相比于基于Hertz模型的高斯拟合法能使理论压痕曲线和实验压痕曲线更吻合;综合考虑细胞的杨氏模量与能量耗散比仅考虑细胞的杨氏模量,更能把不同状态的细胞之间的差异综合地表示出来。实验结果验证了基于Hertz模型的最优化方法相比于基于Hertz模型的高斯拟合法在计算杨氏模量上的优越性,并揭示了综合考虑杨氏模量与能量耗散的必要性。 An optimization method based on Hertz model was proposed and the Young’s modulus of breast cancer cells (MCF-7) after resveratrol culture at different concentrations (0, 50, 100, 150 and 200 μg / mL) And energy dissipation changes. The experimental results show that the optimization method based on Hertz model can make the theoretical indentation curve more consistent with the experimental indentation curve than the Hertz-based Gaussian fitting method. Considering only the Young’s modulus and the energy dissipation ratio of the cells, The Young’s modulus of cells can better express the differences between cells in different states. The experimental results verify the superiority of the Hertz-based optimization method in calculating Young’s modulus compared to the Hertz-based Gaussian fitting method and reveal the necessity of considering Young’s modulus and energy dissipation.