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目的探讨晚发型维生素K缺乏性出血(Late vitamin K deficiency bleeding,LVKDB)患儿疾病急性期及恢复期血小板参数的变化及临床意义。方法回顾性分析24例住院确诊为LVKDB患儿在疾病急性期及恢复期的外周血血红蛋白(Hb)和血小板计数(PLT)、平均血小板体积(MPV)、血小板压积(PCT)、血小板分布宽度(PDW)四项参数,以25例2~3月正常婴儿为对照组。结果 LVKDB患儿急性期与对照组比较,Hb降低,MPV减小,PDW增大,差异有统计学意义(P<0.05);恢复期患儿与对照组比较,Hb降低,差异有统计学意义(P<0.05),而MPV、PDW无明显变化,两者比较差异无统计学意义(P>0.05)。结论 LVKDB患儿在出血急性期Hb明显降低,MPV减小,PDW增大,可作为早期诊断的检测指标之一。
Objective To investigate the changes and clinical significance of platelet parameters in acute and convalescent children with late onset vitamin K deficiency bleeding (LVKDB). Methods Retrospective analysis of 24 cases of hospitalized children with LVKDB at acute and convalescent stages of disease in the peripheral blood hemoglobin (Hb) and platelet count (PLT), mean platelet volume (MPV), platelet pressure (PCT), platelet distribution width (PDW) four parameters to 25 cases of normal infants from February to March as the control group. Results Compared with the control group, the Hb decreased, the MPV decreased and the PDW increased in the acute stage of LVKDB children (P <0.05); Hb decreased in the convalescence group compared with the control group, the difference was statistically significant (P <0.05), while there was no significant difference between MPV and PDW. There was no significant difference between the two groups (P> 0.05). Conclusions Hb in children with LVKDB at acute stage of hemorrhage is obviously decreased, MPV is decreased and PDW is increased, which can be used as one of the detection indexes in early diagnosis.