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目的探讨非糖尿病老年功能性肠病(FBD)患者是否存在自主神经(ANS)功能障碍。方法采用M-314636型肌电诱发电位仪对38例功能性腹泻患者和40例功能性便秘患者的交感皮肤反应(SSR)进行分组检测,并与对照组60例健康老年人比较。结果 FBD患者SSR波引出率显著低于对照组(P<0.01)。与健康老年人比较,FBD患者SSR波潜伏期显著延长(P<0.01),便秘型FBD潜伏期延长更明显,显著长于腹泻型FBD(P<0.05);SSR波波幅则较对照组明显降低(P<0.01)。结论老年FBD患者SSR波引出率下降,潜伏期延长,波幅降低,ANS功能异常明确,这种异常可能是中枢性的。
Objective To investigate whether dysfunction of autonomic nervous system (ANS) is present in non-diabetic elderly patients with functional bowel disease (FBD). Methods M-314636 EMG was used to detect the sympathetic skin reaction (SSR) in 38 patients with functional diarrhea and 40 patients with functional constipation. The results were compared with 60 healthy controls in the control group. Results The incidence of SSR wave in FBD patients was significantly lower than that in the control group (P <0.01). Compared with healthy controls, FBD patients had significantly longer SSR wave latency (P <0.01), longer duration of constipation FBD latency (P <0.05), and lower amplitude of SSR wave (P < 0.01). Conclusions The lead-out rate of SSR wave in elderly patients with FBD is lower, the latency is longer, the amplitude is lower and the function of ANS is abnormal. The abnormality may be central.