为期3～6年药物一级预防能降低高危患者的糖尿病发生率。然而,有些药物只是通过降低患者血糖水平,暂时掩盖基本病变过程(即延缓糖尿病发生),并非能纠正引起糖尿病的基本病变过程(即达到一级预防作用)。本文围绕近年报道的相关临床研究证据,综述药物对2型糖尿病的一级预防效果。 A 3- to 6-year drug primary prevention can reduce the incidence of diabetes in high-risk patients. However, some drugs only temporarily mask the underlying pathological changes (ie delay the onset of diabetes) just by lowering blood glucose levels in patients and do not correct the underlying pathological process leading to diabetes (ie, achieving primary prevention). This article focuses on recent clinical evidence reported in recent years, review the first-line prevention of type 2 diabetes mellitus.