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缺氧诱导因子脯氨酰羟化酶(PHD)作为氧感受器,通过氧依赖性途径催化缺氧诱导因子(HIF)特定的脯氨酸残基发生羟化反应,从而介导缺氧诱导因子降解,对缺氧诱导因子转录活性有影响。PHD表达受多种途径调控,其活性也受分子氧、二价铁、抗坏血酸、三羧酸循环中间产物等多种因素影响。此外PHD与肿瘤的发生发展有关。故对于PHD的深入研究有助于我们认识肿瘤发生发展的机制,为肿瘤的治疗提供更有效的方法。
Hypoxia-inducible factor prolyl hydroxylase (PHD), as an oxygen sensor, catalyzes the hydroxylation of specific proline residues in hypoxia inducible factor (HIF) through an oxygen-dependent pathway and thus mediates hypoxia inducible factor degradation , Have an impact on hypoxia inducible factor transcriptional activity. PHD expression is regulated by a variety of pathways, and its activity is also affected by many factors such as molecular oxygen, ferrous iron, ascorbic acid, and tricarboxylic acid cycle intermediates. In addition PHD and the occurrence and development of cancer. Therefore, in-depth study of PHD helps us understand the mechanism of tumor development and provide a more effective method for the treatment of cancer.