在广岛、长崎的重度辐照的原子弹幸存者中,已观测到,其白血病和癌的发病率是很高的。另外还发现,他们的T淋巴细胞和骨髓细胞有中度到高度的染色体畸变。由于在技术上获得单纯的B细胞的有丝分裂有困难,出现在这种细胞中的染色体畸变尚未得到实验的证实。作者建立了一种新方法供培养对EB病毒敏感的B淋巴细胞使用,即先在琼脂上形成集落, Among the heavily irradiated atomic bomb survivors in Hiroshima and Nagasaki, it has been observed that the incidence of leukemia and cancer is very high. It has also been found that their T lymphocytes and bone marrow cells have moderate to high chromosomal aberrations. Due to technical difficulties in obtaining simple mitosis of B cells, chromosomal aberrations in such cells have not been experimentally confirmed. The authors established a new method for the culture of B-lymphocytes sensitive to Epstein-Barr virus, that is to form colonies on agar.