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为探讨母亲血铅对其婴幼儿智力和精神运动发育的影响。选择在沈阳市 3个区居住的新婚夫妇 ,对其跟踪调查 ,采集并测定孕前、孕中、产前妇女的静脉血血铅浓度和脐带血血铅浓度 ,并对小孩出生后的不同时期测量的智力发育指数(MDI)和精神运动发育指数 (PDI)与其母亲的血铅浓度和脐带血铅浓度进行相关分析和逐步回归分析。结果表明 :2 3 3例新婚妇女孕前时期的血铅浓度为 11 5 8μg/dl;70例孕早血和 66例产前血及 76例脐带血的平均铅水平分别为 9 2 3 μg/dl、8 2 8μg/dl、7 70 μg/dl。对 6～ 3 0个月的婴幼儿每 6个月测定一次MDI的均数值分别 为 10 1 86、10 9 0 6、10 4 0 0、10 7 5 5、113 4 5 ;PDI的均数值分别为 10 4 5 1、10 8 2 5、10 5 61、116 89、114 0 7。婴幼儿不同时期的MDI和PDI与母亲不同时期的血铅水平和脐带血铅水平呈负相关。结论是高血铅暴露对婴幼儿的智商产生不利影响。
To explore the impact of maternal blood lead on their mental and physical development in infants and young children. Newly-married couples living in three districts of Shenyang were selected to follow-up survey, blood lead concentration and cord blood lead concentration were collected and measured before pregnancy, during pregnancy, and prenatal women, and measured at different times after birth (MDI) and psychomotor developmental index (PDI) were compared with their mothers’ blood lead concentrations and umbilical cord blood lead concentrations for stepwise regression analysis. The results showed that the blood lead concentration of pre-pregnancy in 233 pregnant women was 11 5 8 μg / dl. The average lead levels in 70 pregnant premature blood and 66 prenatal blood and 76 cases of umbilical cord blood were 9 2 3 μg / dl , 8 2 8 μg / dl, 7 70 μg / dl. The mean values of MDI measured every 6 months in infants and young children between 6 and 30 months were 10 1 86,10 9 0 6,10 4 0 0,10 7 5 5,113 4 5 respectively; 10 4 5 1,10 8 2 5,10 5 61,116 89,114 0 7. The MDI and PDI in infants and young children at different periods have a negative correlation with blood lead levels and cord blood lead levels in different periods of mothers. The conclusion is that high blood lead exposure has an adverse effect on the IQ of infants and young children.