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目的 研究VEGF在喉癌转移及复发中的作用。方法 通过对 40例喉癌及转移淋巴结的VEGF免疫荧光染色 ,研究喉复发癌及转移癌的VEGF表达特性 ,并通过图像分析系统 ,分析其表达量 ,研究VEGF与喉癌转移的关系。结果 喉癌血管内皮细胞有较强的VEGF表达 ,有转移的喉原发癌及复发癌中VEGF染色强于无转移的原发癌 ,统计学比较具显著性差异 (P <0 .0 5)。结论 VEGF为血管内皮细胞浆表达蛋白 ,肿瘤细胞具有VEGF蛋白分泌功能 ,VEGF的过度表达与喉癌的转移、复发有关。VEGF的过度表达 ,是提示不良预后的有价值的生物学指标
Objective To study the role of VEGF in the metastasis and recurrence of laryngeal carcinoma. Methods The expression of VEGF in laryngeal and metastatic carcinoma of the larynx was studied by immunofluorescence staining of VEGF in 40 cases of laryngeal cancer and metastatic lymph nodes. The expression of VEGF was analyzed by image analysis system, and the relationship between VEGF and laryngeal carcinoma metastasis was studied. Results The VEGF expression in laryngeal carcinoma vascular endothelial cells was stronger than that in primary laryngeal carcinoma with metastatic laryngeal carcinoma and in primary carcinoma without metastasis. There was a significant difference between the two groups (P <0.05) . Conclusions VEGF is a protein expressed in vascular endothelial cells and secreted by VEGF in tumor cells. The overexpression of VEGF is related to the metastasis and recurrence of laryngeal carcinoma. Overexpression of VEGF is a valuable biological indicator of poor prognosis