生殖支原体感染和HIV感染相关性的Meta分析

来源 :中国循证医学杂志 | 被引量 : 0次 | 上传用户:crazy5555
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
目的系统评价生殖支原体感染和HIV感染之间的相关性。方法计算机检索MEDLINE、ScienceDirect、EMbase、WanFang Data、CNKI数据库,收集有关生殖支原体和HIV感染相关性的独立队列研究、病例-对照研究以及横断面研究,并追溯所获文献的参考文献,检索时限截至2012年3月。按纳入和排除标准筛选文献、提取资料和评价质量后,采用RevMan 4.2及SAS 9.1.3进行统计分析。结果最终纳入19个研究,共3 430例HIV感染人群和7 656例对照人群。Meta分析结果显示,HIV感染人群中生殖支原体检出率明显高于对照人群差异有统计学意义[OR=2.34,95%CI(1.68,3.28),P<0.000 01]。亚组分析和敏感性分析结果同上述结果一致。结论生殖支原体感染和HIV感染之间存在密切关联,但具体机制仍待进一步研究。受纳入研究质量和数量所限,上述结论尚需今后开展更多高质量的研究加以验证和更新。 Objective To systematically evaluate the correlation between mycoplasma genitalium infection and HIV infection. METHODS: Independent cohort studies, case-control studies and cross-sectional studies on the correlation between mycoplasma genitalium and HIV infection were collected by computer searches of the MEDLINE, ScienceDirect, EMbase, WanFang Data, and CNKI databases, and the literature references were retrieved retrospectively. March 2012. According to the inclusion and exclusion criteria, the literature was screened, the data were extracted and the quality was evaluated. Statistical analysis was performed using RevMan 4.2 and SAS 9.1.3. The results eventually included 19 studies with a total of 3 430 HIV-infected and 7 656 control subjects. Meta-analysis showed that the detection rate of Mycoplasma genitalium in HIV-infected population was significantly higher than that of the control group [OR = 2.34,95% CI (1.68,3.28), P <0.000 01]. Subgroup analysis and sensitivity analysis results are consistent with the above results. Conclusion There is a close relationship between mycoplasma genitalium infection and HIV infection, but the exact mechanism remains to be further studied. Due to the limited quality and quantity of the research, the above conclusion still needs more high-quality research to be verified and updated in the future.
其他文献
目的观察血液灌流治疗急性毒鼠强中毒的临床疗效。方法纳入本院2012年1月~2013年6月期间诊断为急性毒鼠强中毒的患者共40例。随机分为治疗组和对照组各20例。对照组给予中毒
医学遗传学的研究领域最初主要限于罕见病--例如先天性心脏病、心肌病和心律失常--它们具有较高的外显性,并且符合孟德尔遗传学的基规律;
目的系统评价中国人细胞毒性T淋巴细胞相关抗原4(cytotoxic T lymphocytes associated antigen-4,CTLA-4)基因第一外显子49位点A/G、启动子-318位点C/T多态性与Graves病(Grav
目的:研究分析微创经椎间孔腰椎体间融合术对于腰椎管狭窄合并腰椎不稳定的治疗效果。方法挑选本院70例患者,将他们随机分为观察组和对照组各35例,对他们采取不同的手术方法,研究
目的:分析并总结硬脊膜外蛛网膜囊肿的临床特点、诊疗措施,分析其预后。方法回顾分析2005年1月~2013年12月本院收治的7例硬脊膜外蛛网膜囊肿患者的临床资料。结果①临床表现:4
期刊