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目的探讨左甲状腺素钠片治疗妊娠并甲状腺功能减退对孕妇血清Hcy、SOD水平的影响。方法将206例妊娠合并甲状腺功能低下患者随机分为试验组和对照组各103例。试验组给予左甲状腺素钠片治疗,对照组给予基础药物治疗。观察2组患者治疗前后血清Hcy和SOD水平变化。结果治疗前2组血清Hcy和SOD水平差异均无统计学意义(P>0.05)。治疗后2组患者血清Hcy水平均明显降低,而SOD水平均有所升高,且试验组波动幅度远大于对照组,差异均具有统计学意义(P<0.05)。结论左甲状腺素钠片治疗妊娠合并甲状腺功能减退可有效恢复患者血清Hcy、SOD水平,值得临床推广应用。
Objective To investigate the effect of levothyroxine sodium tablets on serum Hcy and SOD levels in pregnant women with pregnancy and hypothyroidism. Methods 206 cases of pregnancy with hypothyroidism were randomly divided into experimental group and control group of 103 cases. The experimental group was given levothyroxine sodium tablets, the control group was given basic drug treatment. The changes of serum Hcy and SOD levels in two groups before and after treatment were observed. Results There was no significant difference in serum Hcy and SOD levels between the two groups before treatment (P> 0.05). After treatment, serum Hcy levels in both groups were significantly decreased, while SOD levels were increased, and the fluctuation range of the experimental group was much larger than that of the control group, the differences were statistically significant (P <0.05). Conclusion Levothyroxine sodium tablets treatment of pregnancy with hypothyroidism can effectively restore the serum levels of Hcy, SOD, worthy of clinical application.