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目的:通过对我院20例静脉滴注骨瓜提取物所致的不良反应报告进行分析,探讨其不良反应(adverse drug reaction,ADR)发生的规律和临床表现,提示临床注意监测其不良反应,避免严重后果。方法:对20例静脉滴注骨瓜提取物的不良反应报告进行归类及分析。结果:骨瓜提取物所致不良反应多在用药30 min内发生,主要的不良反应是过敏反应和皮肤损害。临床表现主要为胸闷、头晕、头痛、心慌、心悸、呼吸困难、呼吸急促、血压降低、皮疹、瘙痒、皮肤潮红等,此外还可引起过敏性休克等较少见的、严重的不良反应。结论:临床上合理使用骨瓜提取物能减少其不良反应的发生。
OBJECTIVE: To analyze the regularity and clinical manifestation of adverse drug reaction (ADR) in 20 cases of intravenous drip of Bupleurum extract in our hospital, and to remind the clinicians to monitor their adverse reactions, Avoid serious consequences. Methods: 20 cases of intravenous drip Bupleurum extract adverse reactions were classified and analyzed. Results: Adverse reactions of Bupleurum extract were mostly occurred within 30 min after treatment, the main adverse reactions were anaphylaxis and skin damage. Clinical manifestations mainly chest tightness, dizziness, headache, palpitation, heart palpitations, dyspnea, shortness of breath, blood pressure, rash, itching, skin flushing, in addition can also cause allergic shock and other rare and serious adverse reactions. Conclusion: The rational use of Clove extract in clinic can reduce the incidence of adverse reactions.