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本研究的目的是为探讨氧惊厥时,有关脑区亮-脑啡肽(L-Enk)含量的变化。实验中将32只大鼠随机分为常压空气组、高压常氧氮组、高压氧未惊厥组和高压氧惊厥组。用放射免疫法测定了纹状体和下丘脑两个脑区中L-Enk含量的变化。放射免疫结果表明,在高压氧环境中暴露的大鼠纹状体和下丘脑内L-Enk-含量明显升高,且增至一定水平时动物发生惊厥。实验结果提示,动物惊厥与纹状体和下丘脑内L-Enk含量的增加呈正相关,而与环境高气压本身无显著关系。
The purpose of this study was to investigate the changes in brain-area enkephalin-enkephalin (L-Enk) levels during oxy-seizures. In the experiment, 32 rats were randomly divided into normal pressure air group, high pressure normoxia group, hyperbaric oxygen without convulsion group and hyperbaric oxygen convulsion group. The changes of L-Enk in two brain regions of striatum and hypothalamus were determined by radioimmunoassay. Radioimmunoassay results showed that the content of L-Enk- in striatum and hypothalamus of rats exposed to hyperbaric oxygen environment was significantly increased, and when the animals reached a certain level, convulsions occurred. The experimental results suggest that animal convulsions are positively correlated with the increase of L-Enk content in the striatum and hypothalamus, but not with the high atmospheric pressure itself.