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本文叙述从3-(隣氨基苯基)-丙醇开始經过五步反应合成3-(隣二氯乙酰氨甲基-对硝基苯基)-丙醇。此化合物对結核杆菌607的抑制作用約为氯霉素的十六分之一;对葡萄球菌,大腸杆菌及枯草杆菌無显著抑制作用。
This paper describes the synthesis of 3- (o-dichloroacetamidomethyl-p-nitrophenyl) -propanol starting from 3- (o-aminophenyl) -propanol over five steps. The inhibitory effect of this compound on Mycobacterium tuberculosis 607 is about 1/16 of that of chloramphenicol and no significant inhibitory effect on Staphylococcus aureus, Escherichia coli and Bacillus subtilis.