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目的带状疱疹是一种水痘-带状疱疹病毒引起的皮肤炎性疾病。本研究采用阿昔洛韦软膏联合磺胺嘧啶银霜局部治疗带状疱疹病毒感染后的皮损,并观察其疗效。方法收集2012年11月至2015年3月在本院神经内科住院的状疱疹病人96例,并随机分为治疗组及对照组各48例,治疗组采用阿昔洛韦软膏联合磺胺嘧啶银霜治疗,对照组则仅采用阿昔洛韦软膏治疗,2组患者均予阿昔洛韦0.5g/bid静滴,皮损均局部消毒后换药1次/d。观察5 d和7 d后的皮损变化。结果联合用药5 d和7 d后皮损的痊愈率和有效率均优于单用阿昔洛韦软膏(P<0.05),合并感染率也明显较低(P<0.05)。结论阿昔洛韦软膏联合磺胺嘧啶银霜治疗带状疱疹局部皮损的疗效更佳,具有更好的抗感染作用。
Purpose Herpes zoster is a skin inflammatory disease caused by varicella-zoster virus. In this study, acyclovir ointment combined with sulfadiazine silver cream local treatment of herpes zoster virus infection skin lesions and observe its efficacy. Methods A total of 96 patients with herpes zoster admitted to our department of neurology from November 2012 to March 2015 were randomly divided into treatment group (n = 48) and control group (n = 48). The treatment group was treated with acyclovir ointment combined with sulfadiazine silver cream Treatment, the control group was treated with acyclovir ointment, 2 patients were given acyclovir 0.5g / bid intravenous infusion, skin lesions were disinfected after dressing 1 / d. The changes of the lesions were observed after 5 days and 7 days. Results The cure rate and effective rate of skin lesions were better than acyclovir ointment alone (P <0.05) after 5 and 7 days of combination therapy, and the combined infection rate was also significantly lower (P <0.05). Conclusion Acyclovir ointment combined with sulfadiazine silver cream is effective in treating local skin lesions of herpes zoster and has a better anti-infective effect.