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目的：探讨艾司西酞普兰与曲唑酮治疗抑郁症的临床疗效和安全性。方法将68例抑郁症患者随机分为两组，每组34例，研究组口服艾司西酞普兰治疗，对照组口服曲唑酮治疗，观察6周。于治疗前后采用汉密顿抑郁量表评定临床疗效，副反应量表评定不良反应。结果治疗后两组汉密顿抑郁量表总分均较治疗前显著下降（P＜0.01），研究组治疗1周末汉密顿抑郁量表总分较对照组下降更显著（P＜0.01），显效时间显著快于对照组（P＜0.01）。治疗6周末研究组显效率为64.7％、总有效率为88.2％，对照组分别为58.8％、85.3％，两组显效率、总有效率比较差异无显著性（ P＞0.05）。两组不良反应均较轻微，但研究组治疗各时点副反应量表评分显著低于对照组（ P＜0.05或0.01）。结论艾司西酞普兰与曲唑酮治疗抑郁症疗效显著，总体疗效相当，不良反应轻微，但艾司西酞普兰起效较快，安全性更高，依从性更好。“,”Objective To explore the efficacy and safety of escitalopram and trazodone in the treatment of depression .Methods Sixty‐eight depression patients were randomly assigned to two groups of 34 ones each ,research group took orally escitalopram and control group did trazodone for 6 weeks .Efficacies were assessed with the Hamilton Depression Scale (HAMD) before and after treatment adverse reactions with the Treatment Emergent Symptom Scale (TESS) .Results After treatment the total HAMD scores of both groups lowered more significantly compared with pretreatment (P< 0.01) ,so did that (P< 0.01) and took effect more rapidly (P0.05) .Adverse reactions of both groups were mild ,but each time‐point score of the TESS was significantly lower in re‐search than control group (P< 0.05 or 0.01) .Conclusion Escitalopram and trazodone have an evident effect in depression ,their total efficacies are equivalent and their adverse reactions mild ,but the former takes effect more rapidly ,has higher safety and better compliance .