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[目的]观察化浊软坚汤对免疫性肝纤维化大鼠血清学指标的影响,探讨其作用机制及疗效。[方法]将40只SD大鼠随机分为正常对照(正常)组、模型对照(模型)组、阳性对照组和观察组,每组10只,除正常组外,后3组大鼠造模;阳性对照组造模同时灌服复方鳖甲软肝片;观察组造模同时灌服化浊软坚汤。实验结束取大鼠血清检查肝功能[丙氨酸氨基转移酶(ALT)、天冬氨酸转氨酶(AST)]及肝纤维化指标[透明质酸(HA)、层黏连蛋白(LN)]。[结果]观察组ALT、AST、HA、LN均较模型组明显降低(均P<0.05)。[结论]化浊软坚汤以浊毒立论,具有抗纤维化作用。
[Objective] To observe the effect of Huazhuo Ruanjian Decoction on serological indexes of rats with immune fibrosis and explore its mechanism of action and curative effect. [Methods] 40 SD rats were randomly divided into normal control (normal) group, model control (model) group, positive control group and observation group, 10 in each group. Except the normal group, the latter 3 groups were modeled. The positive control group was modeled and fed with compound Biejia Ruangan tablets; the observation group was modeled and fed with Huazhuo Ruanjian Tang. At the end of the experiment, rat serum was taken to examine liver function [alanine aminotransferase (ALT), aspartate aminotransferase (AST)] and liver fibrosis indexes [hyaluronic acid (HA), laminin (LN)] . [Results] The ALT, AST, HA and LN in the observation group were significantly lower than those in the model group (all P<0.05). [Conclusion] The Huazhuo Ruanjian Decoction has the anti-fibrosis effect, which is based on turbidity.