论文部分内容阅读
应用１００μｇ／ｍｌ／ｄＮ－甲基－Ｎ＇－硝基－Ｎ－亚硝基胍（ＭＮＮＧ）溶液喂养５０只Ｗｉｓｔａｒ大鼠，连续９个月，并在前６周内，每周一次１ｍｌ饱和氯化钠溶液灌胃，结果发现，大鼠自然死亡１１只（２２．０％），其中喂ＭＮＮＧ６个月内死亡７只，无胃癌发生，７～９月内死亡４只，胃癌１只。第９个月后３９只存活的大鼠全部处死，剖腹检查，胃癌２３只（５８．９％）。癌肿位于胃窦小弯侧１９只，大弯侧２只，全胃２只，十二指肠癌５只（１２．７％），病理切片诊断高分化腺癌９只，中分化腺癌５只，低分化腺癌４只，未分化腺癌３只及粘液腺癌２只，十二指肠中腺癌２只，粘液腺癌２只和囊腺癌１只
Fifty Wistar rats were fed with 100 μg/ml/d N-methyl-N’-nitro-N-nitrosoguanidine (MNNG) solution for 9 months consecutively and saturated 1 ml once a week for the first 6 weeks. Sodium chloride solution gavage, the results found that the natural death of 11 rats (22.0%), including feeding MNNG within 6 months of the death of 7 patients, no gastric cancer occurred, 7 months died in 4 months, 1 stomach cancer. After the 9th month, all the 39 surviving rats were sacrificed, and laparotomy was performed. There were 23 gastric cancers (58.9%). There were 19 small antrum curvatures, 2 large curvatures, 2 total stomachs, 5 duodenal cancers (12.7%), 9 pathologically diagnosed well-differentiated adenocarcinomas, and moderately differentiated adenocarcinoma. 5, 4 poorly differentiated adenocarcinomas, 3 undifferentiated adenocarcinomas and 2 mucinous adenocarcinomas, 2 adenocarcinomas in duodenum, 2 mucinous adenocarcinomas and 1 cystadenocarcinoma