论文部分内容阅读
他汀类药传统上是作为调脂药应用的,4S研究确立了他汀类药在心脑血管病中治疗及预防的地位,并形成调脂外多功能效应的理论。冠心病患者在心血管病事件后,β受体阻滞剂及阿司匹林各降低心血管病病死率25%,而他汀类药物治疗,可降低42%,作用强度最大,被誉为“心脏药物”〔1〕。经20余年临床实践,治疗适应症不断拓宽,有多种疾病能在治疗中获益且安全可靠。为更好地应用他汀类药物,将有关问题综述如下。
Statins have traditionally been used as lipid-lowering agents. The 4S study establishes the statins’ role in the treatment and prevention of cardiovascular and cerebrovascular diseases and establishes the theory of multifunctional effects outside of the lipid profile. Patients with coronary heart disease after cardiovascular events, β-blockers and aspirin reduce cardiovascular mortality of 25%, while statin therapy can be reduced by 42%, the maximum intensity, known as the “heart drug ”〔1〕. After more than 20 years of clinical practice, treatment indications continue to broaden, a variety of diseases can benefit from the treatment and safe and reliable. To better apply statins, the related issues are summarized below.