论文部分内容阅读
目的探讨神经垂体颗粒细胞瘤(GCT)的临床表现、影像学和病理学特征。方法报道1例神经垂体颗粒细胞瘤,进行形态学观察及免疫组化染色,并复习文献。结果患者男性,36岁。间断性头痛10天。头部MRI显示鞍区占位性病变,T1与T2等信号,不均匀增强。手术全切除肿瘤。镜下见肿瘤由密集上皮样细胞构成,胞质丰富,有较多嗜酸性颗粒,细胞核小,细胞异型性不明显,缺乏核分裂。PAS特殊染色可见胞质内富含阳性颗粒。免疫组化:肿瘤细胞CD68、vimentin和TFE-3弥漫性(+),Ki-67阳性指数为3%,CD1a、S-100、TTF-1、Syn和CgA均(-)。结论神经垂体颗粒细胞瘤是鞍区罕见肿瘤,可能起源于神经垂体的特殊神经胶质细胞,明确诊断依靠病理学检查。
Objective To investigate the clinical manifestations, imaging and pathology of neuropathic pituitary granulosa cell tumor (GCT). Methods One case of neuropituitary granular cell tumor was reported. Morphological observation and immunohistochemical staining were performed. The literature was reviewed. Results The patient was male, 36 years old. Intermittent headache for 10 days. Head MRI showed space-occupying lesions, T1 and T2 signals, uneven enhancement. Surgical removal of the tumor. Microscope see the tumor by the dense epithelium-like cells, rich cytoplasm, more eosinophilic granules, small nucleus, cell atypia is not obvious, the lack of nuclear fission. PAS special staining shows that the cytoplasm is rich in positive particles. Immunohistochemistry showed that CD68, vimentin and TFE-3 diffusely (+) in tumor cells, Ki-67 positive index was 3%, CD1a, S-100, TTF-1, Syn and CgA were both (-). Conclusion Nerve pituitary granulosa cell tumor is a rare tumor in the sellar region, which may originate from the special glial cells of the neurohypophysis. The definite diagnosis depends on the pathological examination.