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目的探讨白细胞介素-31(IL-31)和白细胞介素-33(IL-33)水平变化在子宫内膜癌患者中的临床意义。方法选取子宫内膜癌患者92例为观察组,选取子宫内膜不典型增生以及子宫内膜复杂性增生患者56例为癌前病变组,选取健康体检的志愿者60例为健康对照组,测定3组患者的IL-31和IL-33水平,同时采用免疫发光法测定肿瘤标志物癌胚抗原(CEA)、CA-125、CA19-9水平,分析比较各组患者IL-31、IL-33水平变化及对子宫内膜癌的诊断价值。结果观察组IL-31、IL-33水平明显高于癌前病变组和健康对照组(P﹤0.01);Ⅲ~Ⅳ期子宫内膜癌患者的IL-31、IL-33水平明显高于Ⅰ~Ⅱ期患者(P﹤0.01);ROC曲线分析显示,IL-31的诊断阈值为113.10 pg/ml,AUC为0.973;IL-33的诊断阈值为98.42 pg/ml,AUC为0.929;IL-31和IL-33对子宫内膜癌诊断的敏感度和特异度均高于CEA、CA-125和CA19-9。结论 IL-31和IL-33水平升高在子宫内膜癌的发生发展中发挥着重要作用,IL-31和IL-33对子宫内膜癌具有重要的诊断价值。
Objective To investigate the clinical significance of the changes of interleukin-31 (IL-31) and interleukin-33 (IL-33) levels in patients with endometrial carcinoma. Methods Ninety-two patients with endometrial cancer were selected as the observation group. Fifty-six patients with endometrial dysplasia and endometrial hyperplasia were selected as precancerous lesions group. Sixty healthy volunteers were selected as healthy control group. The levels of IL-31 and IL-33 in the three groups were measured. The levels of carcinoembryonic antigen (CEA), CA-125 and CA19-9 were measured by immunoluminescence assay. The levels of IL-31, IL- Level changes and the diagnostic value of endometrial cancer. Results The levels of IL-31 and IL-33 in observation group were significantly higher than those in precancerous lesions group and healthy control group (P <0.01). The levels of IL-31 and IL-33 in patients with stage Ⅲ ~ Ⅳ endometrial carcinoma were significantly higher than those in group Ⅰ ROC curve analysis showed that the diagnostic threshold of IL-31 was 113.10 pg / ml, the AUC was 0.973, the diagnostic threshold of IL-33 was 98.42 pg / ml, the AUC was 0.929, and the level of IL-31 And IL-33 on the diagnosis of endometrial cancer were higher than the sensitivity and specificity of CEA, CA-125 and CA19-9. Conclusion The elevated levels of IL-31 and IL-33 play an important role in the development of endometrial carcinoma. IL-31 and IL-33 have important diagnostic value for endometrial cancer.