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采用小鼠肉瘤180(S_(180))和人体肿瘤细胞株(人红白血病、K_(562)),观察了大蒜素对顺氯氨铂(DDP)、环磷酰胺(CYT)、5-氟脲嘧啶(5-Fu)、米托蒽醌等抗癌药物的增敏作用。体外实验结果表明:不同浓度的大蒜素(0.001～500mg/L)对人红白血病K_(562)细胞有明显抑制作用,与对照组比较,P<0.001。体内实验结果表明:一次腹腔给予大蒜素(50～200mg/L),除对CYT有些增敏作用外,对上述其它抗癌药并不起增敏作用。而连续给子大蒜素d_(1-?),对抗癌药有增敏作用。提示:适当调整抗癌药物和大蒜素的剂量,同时增加大蒜素给药次数,就可能使大蒜素发挥很好的作用。
Using mouse sarcoma 180 (S_(180)) and human tumor cell lines (human erythroleukemia, K_(562)), allicin was observed for cisplatin (DDP), cyclophosphamide (CYT), 5-fluoro Sensitization of anticancer drugs such as uracil (5-Fu) and mitoxantrone. In vitro results showed that different concentrations of allicin (0.001 ~ 500mg/L) significantly inhibited K562 cells, compared with the control group, P <0.001. The results of in vivo experiments showed that once allicin (50-200 mg/L) was given intraperitoneally, except for some sensitization effects on CYT, it was not sensitizing to other anticancer drugs mentioned above. Continuously administered to the daughter allicin d_(1-?), anti-cancer drug sensitization. Tip: Appropriate adjustment of the dose of anticancer drugs and allicin, while increasing the number of allicin administration, may make allicin play a very good role.