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目的 研究幽门螺杆菌 (Hp)在炎症性肠病 (IBD)患者中的血清学表现以及Hp在IBD发生中的作用。方法 以慢性胃炎为对照配对 (性别相同、年龄相似 )检测 4年间IBD患者血清中抗 -Hp -IgG和抗 -Hp -CagA并分析它们与溃疡性结肠炎 (UC)病变范围的关系。结果 IBD患者共 45例 ,其中UC 40例 ,Crohn病 (CD) 5例 ;抗 -Hp -IgG (+ )率IBD患者 (4 0 0 % )较慢性胃炎(66 7% )低 (χ2 =6 43 ,P <0 0 5 ) ,其中UC患者及其对照分别为 42 5 %和 65 0 % (χ2 =4 0 7,P <0 0 5 ) ,CD患者抗 -Hp -IgG(+ )者为 1/ 5 ;UC患者中抗 -Hp -IgG(+ )率全结肠受累者 (2 8 0 % )比部分结肠受累者 (66 7% )低 (χ2 =5 74,P <0 0 5 ) ;抗 -Hp -CagA(+ )率在IBD及其对照分别为 2 8 9%和 40 0 % (P >0 0 5 ) ,全结肠和部分结肠受累的UC患者分别为 2 8 0 %和 40 0 % (P >0 0 5 )。结论 IBD患者中抗 -Hp -IgG(+ )率处于较高水平 ,但比慢性胃炎低 ;Hp感染对UC的病变范围可能有抑制作用 ;IBD患者及全结肠受累的UC患者抗 -Hp -CagA(+ )率较低 ,但差异无显著性
Objective To study the serological manifestations of Helicobacter pylori (Hp) in patients with inflammatory bowel disease (IBD) and the role of Hp in the pathogenesis of IBD. Methods Anti-Hp-IgG and anti-Hp-CagA in sera of IBD patients were detected by chronic gastritis paired (same gender and age) for four years and analyzed their relationship with the range of ulcerative colitis (UC). Results There were 45 IBD patients, including 40 UC patients and 5 Crohn disease patients. The prevalence of anti-Hp-IgG (+) IBD patients was lower than that of chronic gastritis patients (66.7%) (χ2 = 6 43, P <0 05). The UC patients and their controls were 42.5% and 65.0% respectively (χ2 = 407, P <0.05). The anti-Hp- (2 80%) were lower than those with partial colon involvement (66 7%) in patients with UC (χ2 = 5 74, P 0 05); The rates of anti-Hp-CagA (+) in the IBD and its controls were 29.8% and 40.0%, respectively (P> 0.05). UC patients with total colon and partial colon involvement were 280% and 40% % (P> 0 0 5). Conclusions IBD patients have high level of anti-Hp-IgG (+) but lower than chronic gastritis; Hp infection may have an inhibitory effect on the range of UC; IBD patients and UC patients with colon-specific anti-Hp-CagA (+) Rate is lower, but the difference was not significant