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为探讨病理状态下的中药复方归经,根据中医学“肾主骨”的理论,对地塞米松致骨质疏松大鼠分别予补肾复方(六味地黄丸加淫羊藿、牡蛎等)汤剂灌胃和膏剂穴位敷贴治疗,以cAMP/cGMP比值为指标,观察补肾复方对模型大鼠肝、脾、肾等10种脏器组织细胞内信息调节的影响及其与药物归经的相关性。结果表明,补肾复方对cAMP/cGMP信使变化的调节与中医学本草著作记载的归经有较大的相似性,从而为中药复方归经研究提供了思路与方法。
In order to explore the pathogenesis of traditional Chinese medicine compound prescriptions, according to the theory of “kidney bone” in traditional Chinese medicine, decoction of kidney-invigorating compound (Liu Wei Di Huang Wan plus Epimedium, oyster, etc.) was given to dexamethasone-induced osteoporosis rat respectively. Acupoint application with gavage and ointment was used to observe the effect of Bushen Fufang on the intracellular information regulation of liver, spleen, kidney and other organs in model rats and its correlation with drug-induced menopause . The results showed that the regulation of cAMP/cGMP messenger on the kidney-tonifying compound formula has a greater similarity with that described in the Chinese herbal medicine book, thus providing thoughts and methods for the research on the traditional Chinese compound formula.